Parcours: Fundamental and clinical oncology, towards precision medicine

The objective of the "Basic and clinical oncology, towards precision medicine" subprogram is to provide students with quality training enabling them to pursue a PhD program in the field of oncology. An overview of the most recent research in this area will be provided. This multidisciplinary course is intended for both health professionals and scientists who wish to acquire the conceptual and methodological bases in oncology. It combines basic and clinical research as well as applications to diagnosis and therapy. It is based on the topics developed in expert research structures in this field, at the University of Lille. The program gives an integrated vision of cancer pathology as well as current and future therapies.

Specialization teaching

This non-disciplinary transversal teaching unit offered for all students regardless of their specialization aims to either know how to analyze and interpret autonomously data from experimental or clinical research, or, if these skills are already acquired, to update their knowledge in terms of physiology / pathophysiology and characterization of the major pathologies on which research is focused at the University of Lille (Cancer - Diabetes and cardiovascular diseases - Neurosciences - Inflammation, immunity and infection).

Block of Skills and Knowledge -BCC 3: Develop and implement an experimental approach in Biology and Health.

Elective teaching: 2 teaching subunits (1 choice from 2)

Test: written test

The purpose of this non-disciplinary teaching unit is to provide knowledge regarding the organization of research in France and at the international level, the regulations in bio-medical research and principles of ethics applied to research. It incorporates a presentation of the various research positions and exchanges with professionals.

This non-disciplinary cross-sectional teaching unit aims to allow each student to prepare the research project they will personally conduct during the year of M2.

The purpose of this fundamental disciplinary teaching unit is to provide knowledge enabling students to approach later more specialized courses in the fields of immunity, inflammation and infection. Several teaching subunits (JT) are provided. Each is organized during one day around a specific topic. Student choose six subunits related to their research project and / or essential in their specialization area. During the JT, theoretical concepts are presented through mini-conferences by experts in the field. Teaching through flipping classrooms methods are also used with presentations by students of recent research related to the topic of the day.
Click here to download the sheet of UE 2.1. (PDF, 152 ko)

Elective teaching: 13 teaching subunits (6 choices from 13)

  • EC1:  In vivo study of gene function and regulation. Learn more
  • EC2:  Chromatin and epigenetic regulation.
  • EC3:  Membrane receptors and associated signaling pathways. Learn more
  • EC4:  Nuclear receptors: structure, mechanisms, pathophysiology and study methods.
  • EC5:  Intra- and inter-cellular trafficking. Learn more
  • EC6:  The multiple forms of cell death: pathophysiological implications.
  • EC7:  Mitochondria and pathophysiology. Learn more
  • EC8:  Regulation of food intake and energy homeostasis by the central nervous system.
  • EC9:  Immune responses: dynamics and molecular bases.
  • EC10: Human pathophysiology and ion channels.
  • EC11: Glycopathology, from rare genetic diseases to acquired diseases linked to sugars.
  • EC12: Experimental animal models - phenotypic characterization in metabolic and neurological diseases. Learn more
  • EC13: Introduction to clinical research. 

The purpose of this disciplinary teaching unit is to provide thorough knowledge and the necessary skills for research in the field of oncology.
Click here to download the sheet of UE 2.2. (PDF, 1 mo)

Elective teaching: 9 teaching subunits
Nine teaching subunits of 6 to 12 h are provided. Each subunit takes the form of a seminar on a specific topic, including conferences and mini-symposia. The students are actively associated. They have to choose the equivalent of 10 days from these nine seminars.

  • ST1: Cancer stem cells. Learn more 
  • ST2: Epigenetics and cancer
  • ST3: Tumor immunology and immunotherapy strategies
  • ST4: Tumor dormancy and persistence of residual disease
  • ST5: Tumor Resistance and Targeted Therapy. Learn more 
  • ST6: Tumor Microenvironment, Ionic signaling and metastatic processes. Learn more 
  • ST7: Tumor angiogenesis, fundamental and clinical aspects. Learn more 
  • ST8: Metabolic flexibility of cancer cells
  • ST9: Glycobiology of cancers. Learn more 

This teaching unit aims to provide students with knowledge of recent techniques and equipment used in molecular biology, biochemistry, cell biology and physiology which are essential for a research project in biology applied to health, in the area of oncology.
Click here to download the sheet of UE 3.3. (PDF, 121 ko)

Elective teaching: Fifteen teaching subunits (EC) are available. Students choose 8 in connection with the techniques to be implemented in their research project and / or essential in their specialization.

  • EC1:  Human genetics
  • EC2:  New applications of high throughput gene sequencing
  • EC3:  Proteomics and metabolomics strategies: commonalities and specificities. Learn more (update 9/6/22)
  • EC4:  Inference and interrogation of biological networks. Learn more (update 9/6/22)
  • EC5:  Editing and modification of gene expression
  • EC6:  Viral vectors and their applications. Learn more (update 9/6/22)
  • EC7:  Invertebrate models. Learn more (update 9/6/22)
  • EC8:  Cell culture systems for organ modeling
  • EC9:  Microfluidics, Organ-on-a-chip and Mechanobiology
  • EC10: Flow cytometry
  • EC11: Super-resolution and correlative imaging
  • EC12: Single cell electrophysiology: pharmacological applications
  • EC13: Preclinical imaging. Learn more (update 9/6/22)
  • EC14: Medical imaging. Learn more (update 9/6/22)
  • EC15: Making organs transparent   
  • EC16: Meta-analysis. Learn more (update 9/6/22)
  • EC17: Machine learning and artificial intelligence methods. Learn more (update 9/6/22)
  • EC18: Drug Discovery and Development: Recent Concepts and Strategies. Learn more (update 9/6/22)
The purpose of this teaching unit is to implement an experimental approach allowing the design and implementation of a project in the field of precision health. This period of professional experience will take place in one of the research units belonging to the University of Lille or to another institution in France or abroad. The internship will be supervised by a professional supervisor, affiliated with the host research unit.
Click here to download the sheet of UE 4.2. (update 9/6/22)